Artificial intelligence (AI) is increasingly used to analyze medical images, materials data and scientific measurements, but many systems struggle when real-world data do not match ideal conditions. Measurements collected from different instruments, experiments or simulations often vary widely in resolution, noise and reliability. Traditional machine-learning models typically assume those differences are negligible—an assumption that can limit accuracy and trustworthiness.Artificial intelligence (AI) is increasingly used to analyze medical images, materials data and scientific measurements, but many systems struggle when real-world data do not match ideal conditions. Measurements collected from different instruments, experiments or simulations often vary widely in resolution, noise and reliability. Traditional machine-learning models typically assume those differences are negligible—an assumption that can limit accuracy and trustworthiness.[#item_full_content]