A new study shows an application of machine-learning directed optimization (ML-DO) that efficiently searches for high-performance design configurations in the context of biohybrid robots. Applying a machine learning approach, the researchers created mini biohybrid rays made of cardiomyocytes (heart muscle cells) and rubber with a wingspan of about 10 mm that are approximately two times more efficient at swimming than those recently developed under a conventional biomimetic approach.A new study shows an application of machine-learning directed optimization (ML-DO) that efficiently searches for high-performance design configurations in the context of biohybrid robots. Applying a machine learning approach, the researchers created mini biohybrid rays made of cardiomyocytes (heart muscle cells) and rubber with a wingspan of about 10 mm that are approximately two times more efficient at swimming than those recently developed under a conventional biomimetic approach.[#item_full_content]